LAB LPNS Research

RESEARCH INTERESTS AND METHODS

Research interest	Methods used	Main characterization tools
Self-assembly, crystallization phenomena and production of pure drug nanoparticles	Nanoprecipitation, Nano spray-drying	NMR, FTIR, DLS, NanoSight, X-Rays, DSC, advanced microscopies
Synthesis and characterization of polymeric biomaterials	Microwave-radiation, thermal methods	NMR, FTIR, elemental analysis, GPC, DSC, TGA
New polymeric microcarriers and nanocarriers (mucoadhesive and self-assembly systems)	Nano spray-drying, nanoprecipitation, ionotropic gelation, microencapsulation	DLS, NanoSight, advanced microscopies
Drug encapsulation, delivery and targeting	Various	DLS, NanoSight, HPLC, UV
In vitro and ex vivo studies	Cell culture and mammal tissues (e.g., bovine intestine)	DLS, NanoSight, HPLC, fluorescence, flow cytometry
Preclinical studies	Pharmacokinetics, targeting	Small animals/In collaboration
Clinical studies	Adult healthy volunteers	In collaboration

RELEVANT EXAMPLES OF OUR RESEARCH

NON-COVALENTLY CROSSLINKED AMPHIPHILIC NANOPARTICLES FOR DRUG DELIVERY

Read about this research

https://www.sciencedirect.com/science/article/pii/S073497501500004X?via%3Dihub

https://www.futuremedicine.com/doi/10.2217/nnm.15.191

http://pubs.rsc.org/en/content/articlehtml/2017/bm/c7bm00675f

http://pubs.rsc.org/en/content/articlehtml/2017/bm/c6bm00667a

http://www.mdpi.com/2073-4360/10/5/478

GLUCOSYLATED POLYMERIC MICELLES THAT TARGET PATIENT-DERIVED PEDIATRIC TUMORS

Read about this research

https://www.sciencedirect.com/science/article/pii/S2352940717304766

https://www.sciencedirect.com/science/article/pii/S0168365918301111?via%3Dihub

POLYMER-CERAMIC AMPHIPHILIC NANOPARTICLE-IN-NANOPARTICLE DELIVERY SYSTEMS

Read about this research

https://pubs.acs.org/doi/abs/10.1021/acs.chemmater.6b04922?mi=aayia761&af=R&AllField=nano&target=default&targetTab=std

NANOPARTICLE-IN-MICROPARTICLE DELIVERY SYSTEMS

Read about this research

https://www.sciencedirect.com/science/article/pii/S1742706118302484

Funding


Phyllis and Joseph Gurwin Fund for Scientific Advancement
	NEVET Nanotechnology Grant	Uzi and Michal Halevy Fund
Technion Australia

PRESENTATIONS AVAILABLE IN THE WEB

“Polymeric micelles for oral drug delivery” (in Spanish)

Institution: Faculty of Pharmacy and Biochemistry, University of Buenos Aires

Link: https://docs.google.com/file/d/0ByjUS8JXCeQ8R2ZpOXRJVlhLcnM/preview

“Nanomedicines for children: Minimising the size to maximise the benefit” (in English)

Institution: “Meet the Expert in Paediatric Formulations”-Global Research in Pediatrics (GRiP) Network of Excellence

Link: http://www.grip-network.org/index.php/en/news/item/48

“Polymeric micelles for oral drug delivery” (in Spanish)

Event: International Course on Tissue Engineering, Regenerative Medicine and New Materials for the Design of Drug Delivery Systems in High Socioeconomic Impact Diseases, Bogota, Colombia

Link: https://www.youtube.com/watch?v=nRXGGybK2aA

“Pediatric nanomedicine: The size matters…” (in Spanish)

Event: International Course on Tissue Engineering, Regenerative Medicine and New Materials for the Design of Drug Delivery Systems in High Socioeconomic Impact Diseases, Bogota, Colombia

Link: https://www.youtube.com/watch?v=2ae5qFQxX28

“Finding the Balance between Innovation and Bench-to-bedside Translation in HIV Therapy” (in English)

Event: 7^th CLINAM 2014, Basel, Switzerland

Link: https://www.youtube.com/watch?v=c0-SaQwjl20

RESEARCH INTERESTS AND METHODS

RELEVANT EXAMPLES OF OUR RESEARCH

NON-COVALENTLY CROSSLINKED AMPHIPHILIC NANOPARTICLES FOR DRUG DELIVERY

GLUCOSYLATED POLYMERIC MICELLES THAT TARGET PATIENT-DERIVED PEDIATRIC TUMORS

POLYMER-CERAMIC AMPHIPHILIC NANOPARTICLE-IN-NANOPARTICLE DELIVERY SYSTEMS

NANOPARTICLE-IN-MICROPARTICLE DELIVERY SYSTEMS

Funding

PRESENTATIONS AVAILABLE IN THE WEB

Links to professional and general media