LAB LPNS Publications



Published Papers

  1. Moglioni AG, Martínez AR, Sosnik A, Moltrasio Iglesias GY, Synthesis and study of reactivity in the Diels-Alder reaction of 3-carbometoxi-2(5H)-indano [1,2-b] pyranones, J Chem Res Synop 11, 500-501 (1996).
  2. Cohn D, Sosnik A, Novel reverse thermo-responsive injectable poly(ether carbonate)s, J Mat Sci Mater Med 14, 175-180 (2003).
  3. Sosnik A§, Cohn D, San Román J, Abraham GA, Crosslinkable PEO-PPO-PEO-based reverse thermo-responsive gels as potentially injectable materials, J Biomater Sci Pol Edn 14, 227-239 (2003).
  4. Cohn D, Sosnik A, Levy A, Improved reverse thermo-responsive polymeric systems, Biomaterials 24, 3707-3714 (2003).
  5. Sosnik A§, Cohn D, Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials, Polymer 44, 7033-7042 (2003).
  6. Sosnik A, Cohn D, Ethoxysilane-capped PEO-PPO-PEO triblocks: A new family of reverse thermo-responsive polymers, Biomaterials 25, 2851-2858 (2004).
  7. Sosnik A, Cohn D., Reverse thermo-responsive poly(ethylene oxide) and poly(propylene oxide) multiblock copolymers, Biomaterials 26, 349-357 (2005).
  8. Cohn D, Sosnik A, Garty S, Smart hydrogels for in situ-generated implants, Biomacromolecules 6, 1168-1175 (2005).
  9. Sosnik A, Sefton MV, Semi-synthetic collagen/poloxamine matrices for Tissue Engineering, Biomaterials 26, 7425-7435 (2005).
  10. Sosnik A, Leung B, McGuigan AP, Sefton MV, Collagen/poloxamine hydrogels: Cytocompatibility of embedded HepG2 cells and surface attached endothelial cells, Tissue Eng A 11, 1807-16 (2005).
  11. Sosnik A, Sefton MV, Poloxamine hydrogels with a quaternary ammonium modification to improve cell attachment, J Biomed Mater Res-A 75, 295-307 (2005).
  12. Sosnik A§, Brodersen P, Sodhi RNS, Sefton MV, Surface study of collagen/poloxamine hydrogels by a ‘deep freezing’ ToF-SIMS approach, Biomaterials 27, 2340-2348 (2006).
  13. Sosnik A, Sefton MV, Methylation of poloxamine for enhanced cell adhesion, Biomacromolecules 7, 331-338 (2006).
  14. Cohn D, Lando G, Sosnik A, Garty S, Levi A, PEO–PPO–PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers, Biomaterials 27, 1718-1727 (2006).
  15. Sosnik A, Leung BM, Sefton MV, Lactoyl-poloxamine/collagen matrix for cell-containing modules, J Biomed Mater Res-A 86, 339-53 (2008).
  16. Cohn D, Sosnik A, Malal R, Zarka R, Garty S, Levy A, Chain extension as a strategy for the development of improved reverse thermo-responsive polymers, Polym Adv Technol 18, 731-736 (2007).
  17. Chiappetta DA, Degrossi J, Teves S, D´Aquino M, Bregni C, Sosnik A§, Triclosan-loaded poloxamine micelles for enhanced antibacterial activity against biofilm, Eur J Pharm Biopharm 69, 535-545 (2008).
  18. Carcaboso A, Chiappetta DA, Höcht C, Blake MM, Boccia MM, Baratti CM, Sosnik A§, Melt-molding/compression manufacturing and in vitro-in vivo characterization of gabapentin-loaded poly(epsilon-caprolactone) implants for sustained release in animal studies, Eur J Pharm Biopharm 70, 666-673 (2008).
  19. Gonzalez-Lopez J, Alvarez-Lorenzo C, Taboada P, Sosnik A, Sandez-Macho I, Concheiro A, Self-associative behavior and drug solubilizing ability of poloxamine (Tetronic) block copolymers, Langmuir 24, 10688–10697 (2008).
  20. Aragón DM, Chiappetta DA, Vargas EF, Sosnik A, Martínez F, Solubility of the Antimicrobial Agent Triclosan in Organic Solvents of Different Hydrogen Bonding Capabilities at Several Temperatures, J Chem Eng Data 53, 2576-2580 (2008).
  21. Vargas EF, Sosnik A, Rodríguez F, Application of the Jouyban-Acree model for the estimation of the solubility of naproxen in ethanol/water co-solvent mixtures, Lat Am J Pharm 27, 654-660 (2008).
  22. Torres DR, Sosnik A, Chiappetta DA, Vargas EF, Rodríguez Martínez F, Dissolution enthalpy of sodium sulfacetamide in water: Comparison between solution isoperibolic calorimetry and the Van´t Hoff method, Quim Nova 31, 1455-1459 (2008).
  23. Pacheco DO, Aragón DM, Ruizdíaz MA, Sosnik A, Martínez F, Extended Hildebrand solubility approach in the estimation of naproxen solubility in ethanol/water co-solvent mixtures, Vitae 15, 113-122 (2008).
  24. Aragon DM, Sosnik A, Martínez F, Solution thermodynamics of triclocarban in organic solvents of different hydrogen bonding capability, J Sol Chem 38, 1493-1503 (2009).
  25. Chiappetta DA, Carcaboso AM, Bregni C, Rubio MC, Bramuglia G, Sosnik A§, Indinavir-loaded ph-sensitive microparticles for taste masking: towards extemporaneous paediatric HIV/AIDS liquid formulations with improved patient compliance, AAPS PharmSciTech 10, 1-6 (2009).
  26. Alvarez-Lorenzo C, Rey-Rico A, Brea J, Loza MI, Concheiro A, Sosnik A§, Inhibition of P-glycoprotein pumps by PEO-PPO amphiphiles: Branched versus linear derivatives, Nanomedicine (Lond.) 5, 1371-1383 (2010).
  27. Chiappetta DA, Alvarez-Lorenzo C, Rey-Rico A, Taboada P, Concheiro A, Sosnik A§, N-alkylation of poloxamines modulates micellar encapsulation and release of the antiretroviral efavirenz, Eur J Pharm Biopharm 76, 24-37 (2010).
  28. Moretton MA, Glisoni RJ, Chiappetta DA, Sosnik A§, Molecular implications in the nanoencapsulation of the antituberculosis drug rifampicin within flower-like polymeric micelles, Colloids Surf B: Biointerfaces 79, 467-479 (2010).
  29. Glisoni RJ, Chiappetta DA, Finkielsztein LM, Moglioni AG, Sosnik A§, Self-aggregation behaviour of novel thiosemicarbazone drug candidates with potential antiviral activity, New J Chem 34, 2047-2058 (2010).
  30. Chiappetta DA, Hocht C, Sosnik A§, A highly concentrated and taste-improved aqueous formulation of efavirenz for a more appropriate paediatric management of the anti-HIV therapy, Curr HIV Res 8, 23-31 (2010).
  31. Blake MG, Mariano Boccia M, Carcaboso AM, Chiappetta D, Höcht C, Krawczyk M, Sosnik A, Baratti CM, Novel long-term anticonvulsive treatment with gabapentin without causing memory impairment in mice, Epilepsy & Behavior 17, 157-164 (2010).
  32. Espinosa L, Sosnik A, Fontanilla MR, Development and pre-clinical evaluation of acellular collagen scaffolding and autologous artificial connective tissue in the regeneration of oral mucosa wounds, Tissue Eng A 16, 1667-1679 (2010).
  33. Chiappetta DA, Hocht C, Taira C, Sosnik A§, Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailaibility, Nanomedicine (Lond.) 5, 11-23 (2010).
  34. Kurkalli BGS, Gurevitch O, Sosnik A, Cohn D, Slavin S, Repair of bone defect using bone marrow cells and demineralized bone matrix supplemented with polymeric materials, Curr Stem Cell Res Ther 5, 49-56 (2010).
  35. Carcaboso A, Chiappetta DA, Opezzo AW, Höcht C, Fandiño AC, Croxatto JO, Rubio MC, Sosnik A, Bramuglia GF, Abramson DH, Chantada GL, Episcleral implants for topotecan delivery to the posterior segment of the eye, Invest Ophthamol Vis Sci 51, 2126-2134 (2010).
  36. Peroni RN, Di Gennaro SS, Hocht C, Chiappetta DA, Rubio MC, Sosnik A, Bramuglia GF, Efavirenz is a substrate and in turn modulates the expression of the efflux transporter ABCG2/BCRP in the gastrointestinal tract of the rat, Biochem Pharmacol 82, 1227-1233 (2011).
  37. Cuestas ML, Sosnik A, Mathet VL, Poloxamines display a multiple inhibitory activity of ATP-Binding Cassette (ABC) transporters in cancer cell lines, Mol Pharmaceutics 8, 1152-1164 (2011).
  38. Chiappetta DA, Facorro G, Rubin de Celis E, Sosnik A§, Synergistic encapsulation of the anti-HIV agent efavirenz within poly(ethylene oxide)-poly(propylene oxide) mixed polymeric micelles, Nanomedicine 7, 624-637 (2011).
  39. Chiappetta DA, Hocht C, Taira C, Sosnik A§, Oral pharmacokinetics of the anti-HIV efavirenz encapsulated within polymeric micelles, Biomaterials 32, 2379-2387 (2011).
  40. Gotelli G, Bonelli P, Abraham G, Sosnik A§, Fast and efficient synthesis of high molecular weight poly(epsilon-caprolactone) diols by Microwave-Assisted Polymer Synthesis, J Appl Polym Sci 121, 1321-1329 (2011).
  41. Delgado DR, Sosnik A, Martínez F, Transfer thermodynamics of triclosan from water to organic solvents with different hydrogen bonding capability, Lat Am J Pharm 30, 459-466 (2011).
  42. Cuestas ML, Castillo A, Sosnik A, Mathet VL, Downregulation of mdr1 and abcg2 genes is a mechanism of inhibition of efflux pumps mediated by polymeric amphiphiles, Bioorg Med Chem Lett 22, 6577-6579 (2012).
  43. Glisoni R, Cuestas ML, Mathet VL, Oubiña JR, Moglioni A, Sosnik A§, Antiviral activity against the hepatitis C virus (HCV) of novel 1-indanone thiosemicarbazones and their inclusion complexes with hydroxypropyl--cyclodextrin, Eur J Pharm Sci 47, 596-603 (2012).
  44. Ribeiro A, Sosnik A, Chiappetta DA, Veiga F, Concheiro A, Alvarez-Lorenzo C, Single and mixed poloxamine micelles as suitable nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy, J R Soc Interface 9, 2059-2069 (2012).
  45. Glisoni RJ, Chiappetta DA, Moglioni AG, Sosnik A§, Novel 1-indanone thiosemicarbazone antiviral candidates: Aqueous solubilization and physical stabilization by means of cyclodextrins, Pharm Res 29, 739-755 (2012).
  46. Moretton MA, Chiappetta DA, Sosnik A§, Cryoprotection-lyophilisation and physical stabilization of rifampicin-loaded flower-like polymeric micelles, J R Soc Interface 9, 487-502 (2012).
  47. Cuestas ML, Glisoni RJ, Mathet VL, Sosnik A§, Lactosylated poly(ethylene oxide)-poly(propylene oxide) block copolymers for potential active targeting: Synthesis and physicochemical and self-aggregation characterization, J Nanopart Res 15, 1389 (2013).
  48. Glisoni RJ, García-Fernández MJ, Pino M, Gutkind G, Moglioni AG, Alvarez-Lorenzo C, Concheiro A, Sosnik A§, b-Cyclodextrin hydrogels for the ocular release of antibacterial thiosemicarbazones, Carbohydr Polym 93, 449-457 (2013).
  49. Moretton MA, Chiappetta DA, Andrade F, das Neves J, Ferreira D, Sarmento B, Sosnik A§, Hydrolyzed galactomannan-modified nanoparticles and flower-like polymeric micelles for the active targeting of rifampicin to macrophages, J Biomed Nanotechnol 9, 1076-1087 (2013).
  50. Minaberry Y, Chiappetta DA, Sosnik A, Jobbagy M, Micro/nanostructured hyaluronic acid matrices with tuned swelling and drug release properties, Biomacromolecules 14, 1-9 (2013).
  51. Garcia Vior C, Marino J, Roguin LP, Sosnik A, Awruch J, Photodynamic effects of zinc(II) phthalocyanine-loaded polymeric micelles in human nasopharynx KB carcinoma cells, Photochem Photobiol 89, 492-500 (2013).
  52. Seremeta KP, Chiappetta DA, Sosnik A§, Poly(e-caprolactone), Eudragit® RS 100 and poly(e-caprolactone)/Eudragit® RS 100 blend submicron particles for the sustained release of the antiretroviral efavirenz, Colloids Surf B: Biointerfaces 102, 441-449 (2013).
  53. Chiappetta DA, Hocht C, Opezzo JAW, Sosnik A§, Intranasal administration of antiretroviral-loaded micelles for anatomical targeting to the brain in HIV, Nanomedicine (Lond.) 8, 223-237 (2013).
  54. Glisoni RJ, Sosnik A§, Encapsulation of the antimicrobial and immunomodulator drug nitazoxanide within pristine and lactosylated polymeric micelles, J Nanosci Nanotechnol 14, 4670-4682 (2014).
  55. Imperiale JC, Bevilacqua G, Rosa PTV, Sosnik A§, Production of pure indinavir free-base nanoparticles by a Supercritical Anti-Solvent (SAS) method, Drug Dev Ind Pharm, 40,1607-1615 (2014).
  56. Tshweu L, Katata L, Kalombo L, Chiappetta DA, Hocht C, Sosnik A, Swai H, Enhanced oral bioavailability of the antiretroviral efavirenz nano-encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method, Nanomedicine (Lond.) 9, 1821-1833 (2014).
  57. Moretton MA, Hocht C, Taira C, Sosnik A§, Encapsulation of rifampicin within flower-like polymeric micelles enhances the oral bioavailability in a pediatric fixed dose combination with isoniazid, Nanomedicine (Lond.) 9, 1635-1650 (2014).
  58. Seremeta KP, Martínez Pérez S, López Hernández OD, Höcht C, Taira C, Reyes Tur MI, Sosnik A§, Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability, Colloids Surf B: Biointerfaces 123, 515-523 (2014).
  59. Glisoni RJ, Sosnik A§, Novel poly(ethylene oxide)-co-poly(propylene oxide) copolymer-glucose conjugate by the microwave-assisted ring opening of a sugar lactone, Macromol Biosci 14, 1639-1651 (2014).
  60. Glisoni RJ, Castro EF, Cavallaro LV, Moglioni AG, Sosnik A§, Complexation of 1-indanone thiosemicarbazone with hydroxypropyl-β-cyclodextrin enhances its activity against a Hepatitis C Virus surrogate model, J Nanosci Nanotechnol 15, 4224-4228 (2015).
  61. Monterrubio C, Vila-Ubach M, Rodríguez E, Glisoni RJ, Lavarino C, Schaiquevich P, Sosnik A, Mora J, Carcaboso AM, Combined microdialysis-tumor homogenate method for the study of the steady state compartmental distribution of a hydrophobic anticancer drug in patient-derived xenografts, Pharm Res 32, 2889-2900 (2015).
  62. Jiménez R, Millán D, Suesca E, Sosnik A, Fontanilla MR, Controlled release of an extract of Calendula officinalis flowers from a system based on the incorporation of gelatin-collagen microparticles into collagen I scaffolds: Design and in vitro performance, Drug Deliv Transl Res 5, 209-218 (2015).
  63. Seremeta KP, Höcht C, Taira C, Cortez Tornello PR, Abraham GA, Sosnik A§, Didanosine-loaded poly(epsilon-caprolactone) microparticles by a coaxial electrohydrodynamic atomization (CEHDA) technique, J Mater Chem B 3, 102-111 (2015).
  64. Imperiale JC, Nejamkin P, Del Sole MJ, Lanusse C, Sosnik A§, Novel protease inhibitor Nanoparticle-in-Microparticle Delivery System leads to a dramatic improvement of the oral pharmacokinetics in dogs, Biomaterials 37, 383-394 (2015).
  65. Glisoni RJ, Quintana S, Molina M, Calderon M, Moglioni AG, Sosnik A§, Chitosan-g-oligo(epsilon-caprolactone) polymeric micelles: Microwave-assisted synthesis and physicochemical and cytocompatibility characterization, J Mater Chem B 3, 4853-4864 (2015).
  66. Roma MI, Hocht C, Chiappetta DA, Di Gennaro SS, Minoia JM, Bramuglia GF, Rubio MC, Sosnik A§, Peroni RN, Tetronic® 904-containing polymeric micelles overcome the overexpression of ABCG2 in the blood-brain barrier of rats and boost the penetration of the antiretroviral efavirenz into the central nervous system, Nanomedicine (Lond.) 10, 2325-2337 (2015).
  67. Sosnik A§, Imperiale JC, Vazquez-Gonzalez B, Munoz-Munoz F, Menaker Raskin M, Burillo G, Cedillo G, Bucio E, Mucoadhesive thermo-responsive chitosan-g-poly(NIPAAm) polymeric micelles via a one-pot gamma radiation-assisted pathway, Colloids Surf B Biointerfaces 136, 900-907 (2015).
  68. Monterrubio C, Pascual-Pasto G, Cano F, Vila-Ubach M, Manzanares A, Schaiquevich P, Tornero JA, Sosnik A, Mora J, Carcaboso AM, SN-38-loaded nanofiber matrices for local control of pediatric solid tumors after subtotal resection surgery, Biomaterials 79, 69-78 (2016).
  69. Menaker Raskin M, Schlachet I, Sosnik A§, Mucoadhesive nanogels by ionotropic crosslinking of chitosan-g-oligo(NiPAam) polymeric micelles as novel drug nanocarriers, Nanomedicine (Lond.) 11, 217-233 (2016).
  70. Rasente RY, Imperiale JC, Lázaro-Martínez JC, Gualco L, Oberkersch R, Sosnik A, G Calabrese, Dermatan sulfate/chitosan polyelectrolyte complex with potential application in the treatment and diagnosis of vascular disease, Carbohydr Polym 144, 362-370 (2016).
  71. Sridhar K, Rahman H, Sosnik A, Mukherjee U, Natarajan T, Siram K, Krishnamoorthy B, Production of irbesartan nanocrystals by high shear homogenisation and ultra-probe sonication for improved dissolution rate, Curr Drug Deliv, 13, 688-697 (2016).
  72. Martini MF, Glisoni RJ, Sosnik A, Moglioni AG, Pickholz M, Insights on self-aggregation phenomena of 1-indanone thiosemicarbazones and the formation of inclusion complexes with hydroxypropyl-b-cyclodextrin by Molecular Dynamics simulations, J Mol Liq 222, 963-971 (2016).
  73. Schlachet I, Sosnik A§, Protoporphyrin IX-modified chitosan-g-oligo(NiPAam) polymeric micelles: From physical stabilization to permeability characterization in vitro, Biomater Sci 5, 128-140 (2017).
  74. Abu Saleh D, Shimoni O, Sosnik A§, Novel core-corona hybrid nanomaterials based on the conjugation of amphiphilic polymeric diblocks to the surface of multifunctional nanodiamond anchors, Mater Today Chem 3, 15-26 (2017).
  75. Talal J, Abutbul-Ionita I, Schlachet I, Danino D, Sosnik A§, Amphiphilic nanoparticle-in-nanoparticle drug delivery systems exhibiting a surface rate-controlling crosslinked inorganic domains, Chem Mater 29, 873–885 (2017).
  76. Augustine R, Pan D, Sosnik A, Nguyen T, Kalarikkal N, Vincent B, Thomas S, Menu P, Electrospun poly(vinylidene fluoride-trifluoroethylene)/zinc oxide nanocomposite tissue engineering scaffolds with enhanced  cell adhesion and angiogenic properties, Nano Res 10, 3358-3376 (2017).
  77. Monterrubio C, Paco S, Olaciregui NG, Pascual-Pasto G, Vila-Ubach M, Cuadrado-Vilanova M, Ferrandiz MM, Glisoni R, Kuplennik N, Cheung N-KV, Mora J, Sosnik A, Carcaboso AM, Targeted drug distribution in tumor extracellular fluid of neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8, J Control Release 255, 108-119 (2017).
  78. Cánepa C, Imperiale J, Berini CA, Lewicki M, Sosnik A, Biglione M, Development of a drug delivery system based on chitosan nanoparticles for oral administration of interferon-alpha, Biomacromolecules, 18, 3302-3309 (2017).
  79. Abu Saleh D, Niskanen J, Xue Y, Golberg D, Winnik FM, Sosnik A§, Boron nitride nanotube-based amphiphilic hybrid nanomaterials for superior encapsulation of hydrophobic cargos, Mater Today Chem 6, 45-50 (2017).
  80. Moshe H, Davizon Y, Menaker Raskin M, Sosnik A§, Novel poly(vinyl alcohol)-based amphiphilic nanogels by boric acid non-covalent crosslinking of polymeric micelles, Biomater Sci 5, 2295-2309 (2017).
  81. Bukchin A, Kuplennik N, Carcaboso A, Sosnik A§, Effect of growing glycosylation extents on the self-assembly and active targeting in vitro of branched poly(ethylene oxide)-poly(propylene oxide) block copolymers, Appl Mater Today 11, 57-69 (2018).
  82. Bukchin A, Pascual-Pasto G, Cuadrado-Vilanova M, Castillo-Ecija H, Monterrubio C, Olaciregui NG, Ordeix L, Mora J, Carcaboso AM, Sosnik A§, Glucosylated nanomicelles target glucose-avid pediatric sarcomas, J Control Release 276, 59-71 (2018).
  83. Augustine R, Levin Ashkenazi D, Sverdlov Arzi R, Zlobin V, Shofti R, Sosnik A§, Nanoparticle-in-microparticle oral drug delivery system of a clinically relevant darunavir/ritonavir antiretroviral combination, Acta Biomater 74, 344-356 (2018).
  84. Manzanares A, Restrepo-Perdomo CA, Cano F, Garcia-Alvarez L, Ruiz B, Suñol M, Mora J, Tornero JA, Sosnik A, Carcaboso AM, Tissue biocompatibility of SN-38-loaded anticancer nanofiber matrices, Adv Healthcare Mater 7, 1800255 (2018).
  85. Noi I, Schlachet I, Kumarasamy M, Sosnik A§, Permeability of chitosan-g-poly(methyl methacrylate) amphiphilic nanoparticles in a model of small intestine in vitro, Polymers, 10, 478 (2018). Advanced publication in Preprints (
  86. Mota AH, Direito R, Carrasco M, Rijo P, Ascensão L, Viana A, Rocha J, Eduardo-Figueira M, Rodrigues M, Custódio L, Kuplennik N, Sosnik A, Almeida AJ, Gaspar MM, Reis CP, Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis, Int J Pharm, 559, 13-22 (2019).
  87. Cautela M, Moshe H, Sosnik A, Sarmento B, das Neves J, Composite films for vaginal delivery of tenofovir disoproxil fumarate and emtricitabine, Eur J Pham Biopharm, 138, 3-10 (2019).
  88. Augustine R, Dan P, Schlachet I, Rouxel D, Menu P, Sosnik A§, Chitosan ascorbate improves water uptake capacity and cell adhesion of electrospun poly(epsilon-caprolactone) membranes, Int J Pharm 559, 420-426 (2019).
  89. Schlachet I, Trousil J, Rak D, Knudsen KD, Pavlova E, Nyström B, Sosnik A§, Chitosan-graft-poly(methyl methacrylate) amphiphilic nanoparticles: Self-association and physicochemical characterization, Carbohydr Polym 212, 412-420 (2019).
  90. Moshe Halamish H, Trousil J, Rak D, Knudsen KD, Pavlova E, Nyström B, Štěpánek P, Sosnik A§, Self-assembly and nanostructure of poly(vinyl alcohol)-graft-poly(methyl methacrylate) amphiphilic nanoparticles, J Colloid Interface Sci 553, 512-523 (2019).
  91. Schlachet I, Sosnik A§, Mixed mucoadhesive amphiphilic polymeric nanoparticles cross a model of nasal septum epithelium in vitro, ACS Appl Mater Interfaces 11, 21360–21371 (2019).
  92. 92. Kuplennik N, Sosnik A, Enhanced nanoencapsulation of sepiapterin within PEG-PCL nanoparticles by complexation with triacetyl-beta cyclodextrin, Molecules 24, 2715 (2019). Advanced publication in Preprints.
  93. Kumarasamy M, Sosnik A§, The nose-to-brain transport of polymeric nanoparticles is mediated by immune sentinels and not by olfactory sensory neurons, Adv Biol 3, 1900123 (2019).
  94. Chauhan P, Kumarasamy M, Sosnik A, Danino D, Enhanced thermostability and anticancer activity in breast cancer cells of laccase immobilized on Pluronic-stabilized nanoparticles, ACS Appl Mater Interfaces 11, 39436-39448 (2019).
  95. Zaritski A, Castillo-Ecija H,Kumarasamy M, Peled E, Sverdlov Arzi R, Carcaboso AM, Sosnik A§, Selective accumulation of galactomannan amphiphilic nanomaterials in pediatric solid tumor xenografts correlates with GLUT1gene expression, ACS Appl Mater Interfaces 11, 38483-38496 (2019).
  96. Kuplennik N, Lang K, Steinfeld R, Sosnik A§, Folate receptor a-modified nanoparticles for targeting of the central nervous system, ACS Appl Mater Interfaces 11, 39633-39647 (2019).
  97. Imperiale JC, Schlachet I, Lewicki M, Sosnik A§, Biglione MM, Oral pharmacokinetics of a chitosan-based nano-drug delivery system of interferon alpha, Polymers 11, 1862 (2019). Advanced publication in Preprints (
  98. Blachman A, Funez F, Saavedra SL, Lazaro-Martinez JM, Camperi SA, Glisoni R, Sosnik A, Calabrese GC, Targeted anti-inflammatory peptide delivery in injured endothelial cells using dermatan sulfate/chitosan nanomaterials, Carbohydr Polym 230, 115610 (2020).
  99. Weisbord I, Shomrat N, Moshe H, Sosnik A, Segal-Peretz T, Nano spray-dried block copolymer nanoparticles and their transformation into hybrid and inorganic nanoparticles, Adv Func Mater 30, 1808932 (2020).
  100. Kushnirov Melnitzer V, Sosnik A§, Novel hybrid titanium oxide/polymer amphiphilic nanomaterials with controlled size for drug encapsulation and delivery, Adv Func Mater 30, 1806146 (2020).
  101. Sverdlov Arzi R, Sosnik A§, Cohen N, A microscopically motivated model for particle penetration into swollen biological networks, Polymers 12, 1912 (2020). Advanced publication in Preprints (
  102. Abu Saleh D, Rana U, Higuchi M, Sosnik A§, Luminescent amphiphilic nanogels by terpyridine-metal ion complexation of polymeric micelles, Mater Today Chem 18, 100359 (2020).
  103. Schlachet I, Moshe Halamish H, Sosnik A§, Mixed self-assembled amphiphilic polymeric nanoparticles for intranasal drug delivery to the brain, Molecules 25, 4496 (2020). Advanced publication in Preprints (
  104. Bukchin A, Sanchez-Navarro M, Carrera A, Teixidó M, Carcaboso AM, Giralt E, Sosnik A§, Amphiphilic polymeric nanoparticles modified with a retro-enantio peptide shuttle target the brain of mice, Chem Mater 32, 7679-7693 (2020).
  105. Lecot N, Glisoni R, Oddone N, Benech J, Fernández-Lomonaco M, Gambini JP, Cabral P, Sosnik A§, Glucosylated polymeric micelles actively target a breast cancer model, Adv Ther 4, 2000010 (2021).
  106. Singh Chauhan P, Abutbul Ionita I, Moshe Halamish H, Sosnik A, Danino D, Multidomain drug delivery systems of β-casein micelles for the local oral co-administration of antiretroviral combinations, J Colloid Interface Sci 592, 156-166 (2021).
  107. Bukchin A, Sanchez-Navarro M, Carrera A, Resa-Pares C, Castillo-Ecija H, Balaguer-Lluna L, Teixidó M, Olaciregui NG, Giralt E, Carcaboso AM, Sosnik A§, Amphiphilic polymeric nanoparticles modified with a protease-resistant peptide shuttle for the delivery of SN-38 in diffuse intrinsic pontine glioma, ACS Appl Nano Mater 4, 1314-1329 (2021).
  108. Abu Saleh, Sosnik A§, Enhanced photoluminescence of boron nitride quantum dots by encapsulation in polymeric nanoparticles, Nanotechnology 32, 195104 (2021).
  109. Guo S, Debbi L, Zohar B, Samuel R, Arzi RS, Fried AI, Carmon T, Shevach D, Redenski I, Schlachet I, Sosnik A, Levenberg S, Stimulating extracellular vesicles production from engineered tissues by mechanical forces, Nano Lett 21, 2497-2504 (2021).
  110. Sharipova A, Unger RE, Sosnik A§, Gutmanas E, Dense drug-eluting biodegradable Fe-Ag nanocomposites, Mater Des 204, 109660 (2021).
  111. Sverdlov Arzi R, Kay A, Raychman Y, Sosnik A§, Excipient-free pure drug nanoparticles fabricated by microfluidic hydrodynamic focusing, Pharmaceutics 13, 529 (2021). Advanced publication in Preprints (
  112. Bellotti C, Lang K, Kuplennik N, Sosnik A, Steinfeld R, High-grade extracellular vesicles preparation by combined size-exclusion and affinity chromatography, Sci Rep 11, 10550 (2021). Advanced publication in Research Square
  113. Kumarasamy M, Sosnik A§, Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized neuronanomedicine, iScience 24, 102183 (2021). Advanced publication in bioRxiv (
  114. 114. Singh Chauhan P, Kumarasamy M, Carcaboso AM, Sosnik A, Danino D, Multifunctional silica-coated mixed polymeric micelles for targeted therapy of pediatric glioblastoma multiforme, Mater Sci Eng C Mater Biol Appl 128, 112261 (2021).
  115. Pariente A, Peled E, Zlotver I, Sosnik A§, Hybrid amorphous TiO2/polymer nanomaterials trigger apoptosis of pediatric cancer cells upon ultrasound irradiation, Mater Today Chem 22, 100613 (2021).
  116. Peled E, Sosnik A§, Amphiphilic galactomannan nanoparticles trigger the alternative activation of murine macrophages, J Control Release 339, 473-483 (2021).
  117. Jiménez RA, Millán D, Sosnik A, Fontanilla MR, Collagen-Aloe vera microgels: Physicochemical characterization and biological performance in vitro, Mater Today Chem 23, 100722 (2022).
  118. Sosnik A§, Ben Shabo R, Moshe Halamish H, Cannabidiol-loaded mixed polymeric micelles of chitosan/poly(vinyl alcohol) and poly(methyl methacrylate) for trans-corneal delivery, Pharmaceutics 13, 2142 (2021). Advanced publication in Preprints (
  119. 119. Pascual-Pasto G, Castillo-Ecija H, Unceta N, Aschero R, Resa-Pares C, Gómez-Caballero A, Vila-Ubach M, Muñoz-Aznar O, Suñol M, Burgueño V, Gomez-Gonzalez S, Sosnik A, Ibarra M, Schaiquevich P, de Álava E, Tirado OM, Mora J, Carcaboso AM, SPARC-mediated long-term retention of nab-paclitaxel in pediatric sarcomas, J Control Release 342, 81-92 (2022).
  120. Dobrynin D, Polishchuk I, Portal L, Zlotver I, Sosnik A§, Pokroy B, Adsorption of SARS CoV-2 spike proteins on various functionalized surfaces correlates with the high transmissibility of Delta and Omicron variants, Mater Today Bio 14, 100265 (2022). Advanced publication in arXiv (
  121. Trousil J, Dal N-JK, Fenaroli F, Schlachet I, Kubíčková P, Janoušková O, Pavlova E, Škorič M, Trejbalová K, Pavliš O, Sosnik A§, Antibiotic-loaded amphiphilic chitosan nanoparticles target macrophages and kill an intracellular pathogen, Small 18, 2201853 (2022).
  122. Moshe Halamish H, Zlotver I, Sosnik A§, Polymeric nanoparticles surface-complexed with boric acid actively target solid tumors overexpressing sialic acid, J Colloid Interface Sci 626, 916-929 (2022).
  123. Sverdlov Arzi R, Davidovich-Pinhas M, Cohen N, Sosnik A§, An experimental and theoretical approach to understand the interaction between particles and mucosal tissues, Acta Biomater 158, 449-462 (2023). Advanced publication in bioRxiv (
  124. Sharipova A, Bakina O,  Lozhkomoev A,  Lerner M,  Gutmanas E, Sosnik A§, Drug-eluting biodegradable metals and metal-ceramic composites, Materialia 28, 101756 (2023). Advanced publication in bioRxiv (
  125. Shreiber-Livne I, Sulimani L, Shapira A, Procaccia S, Meiri D, Sosnik A§, Poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles as a platform for the improved oral delivery of cannabidiol, Drug Deliv Transl Res, in press (2023). Advanced publication in Research Square (
  126. Blachman A, Birocco AM, Curcio S, Camperi SA, di Gianvincenzo P, Rodriguez JA, Barredo-Vacchelli GR, Cenci G, Sosnik A, Moya S, Calabrese GC, Dermatan sulfate/chitosan nanoparticles loaded with an anti-inflammatory peptide increase the response of human colorectal cancer cells to 5-fluorouracil, Macromol Biosci, 23, 2300193 (2023).
  127. 127. Peled E, Tornaci S, Zlotver I, Dubnika A, Toksoy Öner E, Sosnik A, First transcriptomic insight into the reprogramming of human macrophages with levan-based fructans, Carbohydr Polym 320, 121203 (2023).
  128. Sosnik A§, Zlotver I, Peled E, Galactomannan-graft-poly(methyl methacrylate) nanoparticles induce an anti-inflammatory phenotype in human macrophages, J Mater Chem B 11, 8471-8483 (2023).
  129. Sharipova A, Zlotver I, Sosnik A, Rabkin E, Solid-state dewetting of thin Au films for surface functionalization of biomedical implants, Materials 16, 7524 (2023).
  130. Zlotver I, Sosnik A§, Glucosylated hybrid TiO2/polymer nanomaterials for actively targeted sonodynamic therapy of cancer, Small 20, 2305475 (2024).

§Corresponding author.

Review Papers (§ indicates corresponding authorship)

  1. Sosnik A§, Injectable biomaterials for biomedical and pharmaceutical applications: Past, present and future of the in situ generated implants, ARS Pharm 48, 83-102 (2007).
  2. Chiappetta DA, Sosnik A§, Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs,Eur J Pharm Biopharm 66, 303-317 (2007).
  3. Sosnik A§, Carcaboso A, Chiappetta DA, Polymeric nanocarriers: New endeavors for the optimization of the technological aspects of drugs, Recent Pat Biomed Eng 1, 43-59 (2008).
  4. Sosnik A§, Chiappetta DA, Carcaboso A, Drug delivery systems in HIV pharmacotherapy: What has been done and the challenges standing ahead, J Control Release 138, 2-15 (2009).
  5. Cuestas ML, Mathet V, Oubiña JR, Sosnik A§, Drug delivery systems and liver-targeting for the improved pharmacotherapy of the Hepatitis B virus (HBV) infection, Pharm Res 27, 1184-1202 (2010).
  6. Sosnik A§, Chiappetta DA, Moretton MA, Glisoni RJ, Carcaboso A, New old challenges in tuberculosis: Potentially effective nanotechnologies in drug delivery, Adv Drug Deliv Rev 62, 547-559 (2010).
  7. Alvarez-Lorenzo C, Rey-Rico A, Sosnik A, Taboada P, Concheiro A, Poloxamine-based nanomaterials for drug delivery, Frontiers Biosci E2, 424-440 (2010).
  8. Andrade F, Goycoolea F, Chiappetta DA, das Neves J, Sosnik A, Sarmento B, Chitosan-grafted copolymers and chitosan-ligand conjugates as matrices for pulmonary drug delivery, Int J Carbohyd Chem 2011, 865704 (2011).
  9. Sosnik A§, Gotelli G, Abraham GA, Microwave-assisted polymer synthesis (MAPS) as a tool in biomaterials science: How new and how powerful, Prog Polym Sci 36, 1050-1078 (2011).
  10. Alvarez-Lorenzo C, Sosnik A, Concheiro A, PEO-PPO block copolymers for passive micellar targeting and overcoming multidrug resistance in cancer therapy, Curr Drug Targets 12, 1112-1130 (2011).
  11. Sosnik A§, Seremeta KP, Imperiale JC, Chiappetta DA, Novel formulation and drug delivery strategies for the treatment of pediatric poverty related diseases, Expert Opin Drug Deliv 9, 303-23 (2012).
  12. Imperiale JC, Sosnik A§, Nanoparticle-in-microparticle delivery systems (NiMDS): Production, routes of administration and clinical potential, J Biomater Tissue Eng 3, 22-38 (2013).
  13. Sosnik A§, Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps with Generally Regarded As Safe (GRAS) nanopharmaceuticals: A review, Adv Drug Deliv Rev 65, 1828-1851 (2013).
  14. Andrade F, das Neves J, Ferreira D, Sosnik A, Sarmento B, Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases, Adv Drug Deliv Rev 65, 1816-1827 (2013).
  15. Sosnik A§, das Neves J, Sarmento B, Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: A review, Prog Polym Sci 39, 2030-2075 (2014).
  16. Sosnik A§, Carcaboso AM, Nanomedicines in the future of pediatric therapy, Adv Drug Deliv Rev 73, 140-161 (2014).
  17. Sosnik A§, Production of drug-loaded polymeric nanoparticles by electrospraying technology, J Biomed Nanotechnol 10, 2200-2217 (2014).
  18. Sosnik A§, Alginate particles for oral drug delivery applications: State-of-the-Art, ISRN Pharm 2014,926157 (2014).
  19. Sosnik A§, Seremeta KP, Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers, Adv Colloid Interface Sci 223, 40-54 (2015).
  20. Imperiale JC, Sosnik A§, Cyclodextrin complexation for the improvement of the treatment in infectious diseases, Nanomedicine (Lond) 10, 1621-1641 (2015).
  21. Sosnik A§, Menaker Raskin M, Polymeric micelles in mucosal drug delivery: Challenges towards clinical translation, Biotechnol Adv 33, 1380-1392 (2015).
  22. Sosnik A§, Drug self-assembly: A phenomenon at the nanometer scale with major impact in the structure-biological properties relationship and the treatment of disease, Prog Mater Sci 82, 39-82 (2016).
  23. Sosnik A§, Augustine R, Challenges in oral drug delivery of antiretrovirals and the innovative strategies to overcome them, Adv Drug Deliv Rev 103, 105-120 (2016).
  24. Augustine R, Mathew A, Sosnik A§, Metal oxide nanoparticles as versatile therapeutic agents modulating cell signaling pathways: Linking nanotechnology with molecular medicine, Appl Mater Today 7, 91-103 (2017).
  25. Sosnik A§, Seremeta KP, Polymeric hydrogels as technology platform for drug delivery applications, Gels 3, 25 (2017).
  26. Imperiale JC, Acosta G, Sosnik A§, Polymer-based carriers for ophthalmic drug delivery, J Control Release 285, 106-141 (2018).
  27. Sverdlov Arzi R, Sosnik A§, Electrohydrodynamic atomization and spray-drying for the production of pure drug nanocrystals and co-crystals, Adv Drug Deliv Rev 131, 79-100 (2018).
  28. das Neves J, Sverdlov Arzi R, Sosnik A§, Molecular and cellular cues governing nanomaterials-mucosae interactions: From nanotherapeutics to nanotoxicology, Chem Soc Rev 49, 5058-5100 (2020).
  29. García-González CA, Sosnik A, Kalmár J, De Marco I, Erkey C, Concheiro A, Alvarez-Lorenzo C, Aerogels in drug delivery: From design to application, J Control Release 332, 40-63 (2021).
  30. Ashkar A, Sosnik A, Davidovich-Pinhas, Structured edible lipid-based oral drug-delivery systems, Biotechnol Adv 54, 107789 (2022).
  31. Awad R, Avital A, Sosnik A§, Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders, Acta Pharm Sin B 13, 1866-1886 (2023).
  32. Peng X, Li X, Xie B, Lai Y, Sosnik A, Boucetta H, Chen Z, He W, Gout therapeutics and drug delivery, J Control Release 362, 728-754 (2023).
  33. Jayita S, Pravinkumar V, Sosnik A§, Kumarasamy M, Microfluidics for brain endothelial-astrocytic interactions, Organs-on-a-Chip 5, 100033 (2023). Advanced publication in Preprints (
  34. Boucetta H, Zhang L, Sosnik A§, He W, Pulmonary arterial hypertension nanotherapeutics: New pharmacological targets and gene therapy, J Control Release 365, 236-258 (2024).

Editorials (§ indicates corresponding authorship)

  1. Sosnik A§, Nanotechnology contributions to the pharmacotherapy of pediatric HIV: A dual scientific and ethical challenge and a still pending agenda, Nanomedicine (Lond.) 5, 833-837 (2010).
  2. Sosnik A§, Amiji M, Nanotechnology solutions for infectious diseases in developing nations, Adv Drug Deliv Rev 62, 375-377 (2010).
  3. Sarmento B, Goycoolea FM, Sosnik A, das Neves J, Chitosan and chitosan derivatives for biological applications: Chemistry and functionalization, Int J Carbohydr Chem 2011, Article ID 802693 (2011).
  4. Abraham GA, Romero EL, Sosnik A, Nanomedicine in Latin America, J Biomater Tissue Eng 3, 1-3 (2013).
  5. Dintiz SN, Sosnik A, Mu H, Valduga CJ,Nanobiotechnology, BioMed Res Int
    2013, Article ID 319832 (2013).
  6. Calderon M, Sosnik A§, Polymeric soft nanocarriers as smart drug delivery systems: State-of-the-Art and future perspectives, Biotechnol Adv 33, 1277-1278 (2015).
  7. das Neves J, Sarmento B, Sosnik A§, Biomedical engineering approaches for HIV/AIDS prophylaxis, diagnostics and therapy, Adv Drug Deliv Rev 103, 1-4 (2016).
  8. Sosnik A§, Mühlebach S, Drug nanoparticles and nano-cocrystals: From production and characterization to clinical translation, Adv Drug Deliv Rev 131, 1-2 (2018).
  9. He W, Sosnik A§, Xu C, Special Column on Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection, Acta Pharm Sin B 13, 2296-2297 (2023).

Chapters in books (§ indicates corresponding authorship, all invited chapters)

  1. Sosnik A, Khan OF, Butler M, Sefton MV, Poloxamine hydrogels: From non-cell adhesive substrates to matrices with improved cytocompatibility for Tissue Engineering applications, In: Hydrogels: Biological properties and applications, Barbucci R. (Ed.), pp. 79-96, Springer (2009).
  2. Chiappetta DA, Degrossi J, Lizarazo RA, Salinas DL, Martínez F, Sosnik A§, Molecular implications in the solubilization of the antibacterial agent triclocarban by means of branched poly(ethylene oxide)-poly(propylene oxide) polymeric micelles, In: Polymer Aging, Stabilizers and amphiphilic block copolymers, Segewicz L. and Petrowsky M. (Eds.), Chapter 5, pp. 197-211, Nova Publishers (2011).
  3. Alvarez-Lorenzo C, dos Santos FR, Sosnik A, Torres-Labandeira J, Concheiro A, Cyclodextrin-based hydrogels as highly versatile drug delivery systems, In: Handbook of hydrogels: Properties, preparation and applications, Stein DB (Ed.), Chapter 3, pp. 61-102, Nova Publishers (2009).
  4. Alvarez-Lorenzo C, Concheiro A, Sosnik A§, Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles and gels in drug delivery: State-of-the-art and future perspectives, In: Handbook of hydrogels: Properties, preparation and applications, Stein DB (Ed.), Chapter 15, pp. 449-484, Nova Publishers (2009).
  5. Sosnik A§, Temperature- and pH-sensitive polymeric micelles for drug encapsulation, release and targeting, In: Smart Materials for Drug Delivery, Alvarez-Lorenzo C, Concheiro A (Eds.), Chapter 5, pp. 115-147, Royal Society of Chemistry (2013).
  6. Sosnik A§, Gotelli G, Aplicaciones de la tecnología de radiación de microondas en la síntesis y el procesamiento de biomateriales, In: Biomateriales aplicados al diseño de sistemas terapéuticos avanzados, Sosnik A, Braga M, Sousa H (Eds.), Chapter 7, pp. 255-308, Coimbra University Press (2015).
  7. Alvarez-Lorenzo, Concheiro A, Sosnik A§, Micelas poliméricas para encapsulación, vectorización y cesión de fármacos, In: Biomateriales aplicados al diseño de sistemas terapéuticos avanzados, Sosnik A, Braga M, Sousa H (Eds.), Chapter 5, pp. 183-217, Coimbra University Press (2015).
  8. Sosnik A§, Tissue-based in vitro and ex vivo models for nasal permeability studies, In: Concepts and models for drug permeability studies: Cell and tissue-based in vitro culture models, 1st Edition, Sarmento B (Ed.), Chapter 4.3, pp. 237-254, Woodhead Publishing (2015).
  9. Suesca E, Sosnik A, Fontanilla MR, Collagen substrates for soft tissue engineering, In: Frontiers in Biomaterials, Vo. 2, Pillay V, Choonara YE, Kumar P (Eds.), Chapter 2, pp. 28-53, Bentham Science Publishers (2016).
  10. Sosnik A§, Aliphatic polyester micro- and nanosystems for treating HIV, tuberculosis and malaria, In: Handbook ofpolyesterdrug delivery systems, Kumar R (Ed.), Chapter 17, pp. 563-594, Jenny Stanford Publishing Ltd. (2016).
  11. Sosnik A§, Nanodrugs in medicine & healthcare: Oral delivery, In: Nanopharmacy – Nanotechnology-based Production of Pharmaceuticals, Cornier J, Kwade A, Owen A, Van de Voorde M (Eds.), Chapter 24, pp. 579-601, Wiley-VCH (2016).
  12. Sosnik A§, From the “Magic Bullet” to Advanced Nanomaterials for Active Targeting in Diagnostics and Therapeutics, In: Biomedical Applications of Functionalized Nanomaterials, Sarmento B, das Neves J (Eds.), Chapter 1, pp. 1-32, Woodhead Publishing (2018).
  13. 13. Seremeta KP, Sosnik A, Hidrogeles de uso farmacéutico, In: Tópicos de Tecnología Farmacéutica, Nacucchio M, Manzo R (Eds.), Chapter 15, pp. 413-437, Press of the University of Buenos Aires – EUDEBA (2019).
  14. Kumarasamy M, Sosnik A§, Overcoming efflux transporter-mediated resistance in cancer by using nanomedicines, In: Drug Efflux Pumps In Cancer Resistance Pathways: From Molecular Recognition To Inhibition Strategies In Chemotherapy, Sosnik A, Bendayan R (Eds.), Chapter 11, pp. 337-369, Academic Press (2020).
  15. Seremeta K, Sosnik A§, Delivery platforms for oral drug administration, In: Nanotechnology for Oral Drug Delivery: From Concept to Applications, Santos H, Martins JP (Eds.), Chapter 10, pp. 199-224, Academic Press (2020).
  16. Sosnik A§, Alginate particulate gels for oral drug delivery, In: Soft Matter for Biomedical Applications, Azevedo H, Mano J, Borges J (Eds.), Chapter 7, pp. 154-178, Royal Society of Chemistry (2021).
  17. Seremeta KP, Sosnik A§, Natural and semi-natural polymers, In: Biomaterials and Biopolymers. AAPS Introductions in the Pharmaceutical Sciences, Vol 7., Farah S, Mizrahi B, Domb A (Eds.), Springer-Nature, in press.
  18. Porfiryeva N, Sosnik A§, Tissue-based in vitro and ex vivo models for nasal permeability studies, In: Concepts and models for drug permeability studies: Cell and tissue-based in vitro culture models, 2nd Edition, Sarmento B, Pereira C, das Neves J (Eds.), pp. 347-371 (2024).

Patents and patent applications

  1. Cohn D, Sosnik A, Responsive biomedical composites, U.S. #7,425,322.
  3. Sosnik A, AMPHIPHILIC POLYMERS, PROCESS OF PREPARING SAME AND USES THEREOF, Provisional US Patent Application 62/684,829, WO2019239416, US Patent Application 20210115177.
  4. Sosnik A, Kushnirov Melnitzer V, Hybrid polymer-ceramic particles, methods for preparing the same and uses thereof, Provisional U.S. Patent Application 62/718,014, WO2020035858, US Patent Application 20210177759, EP3836968.
  5. Carcaboso AM, Sosnik A, Resa-Pares C, Teixido Tura M, PEPTIDIC WATER-SOLUBLE DELIVERY SYSTEM OF ANTICANCER DRUGS, Patent Application EP22382287.

Edition of Special Journal Issues and Books

(A) Journals

  1. Nanotechnology solutions for infectious diseases in developing nations. Advanced Drug Delivery Reviews 62, 375-590 (2010). Editors: Sosnik A, Amiji M.
  2. Chitosan and chitosan derivatives for biological applications: Chemistry and functionalization. International Journal of Carbohydrate Chemistry 2011 (2011). Editors: Sarmento B, Goycoolea F, Sosnik A, das Neves J.
  3. Nanomedicines in Latin America. Journal of Biomaterials and Tissue Engineering, 3, Pages 1-172 (2013). Editors: Abraham GA, Romero E, Sosnik A.
  4. Nanobiotechnology. BioMed Research International 2013 (2013). Editors: Valguga CJ, Mu H, Sosnik A, Diniz SN.
  5. Polymeric soft nanocarriers as smart drug delivery systems: State-of-the-Art and future perspectives. Biotechnology Advances 33, 1277-1392 (2015). Editors: Calderon M, Sosnik A.
  6. Biomedical engineering approaches for HIV/AIDS prophylaxis, diagnostics and therapy, Advanced Drug Delivery Reviews 103, 1-218 (2016). Editors: das Neves J, Sarmento B, Sosnik A.
  7. Hydrogels for Drug Delivery, Gels 3 (2017). Editors: Sosnik A, Seremeta KP.
  8. Drug Nanoparticles and Nano-Cocrystals: From Production and Characterization to Clinical Translation, Advanced Drug Delivery Reviews 131, 1-132 (2018). Editors: Sosnik A, Mühlebach S.
  9. Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection, Acta Pharmaceutica Sinica B 13 (2023). Editors: He W, Sosnik A, Xu C.

(B) Books

  1. Biomateriales aplicados al diseño de sistemas terapéuticos avanzados. Coimbra University Press (2015). Editors: H Sousa, M Braga, A Sosnik.
  2. Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition to Inhibition Strategies in Chemotherapy. 1st Edition, Academic Press (2020). Editors: Sosnik A, Bendayan R.


(A) Plenary and keynote

  1. “Advances in Nanotechnologies Applied to Therapeutics”. VI Conference of the Pan American Network on Drug Regulatory Harmonization-Pan American Health Organization (PAHO). Brasilia, Brazil 2011. Keynote
  2. “Where self-assembly meets pharmaceutical nanomaterials science: Some lessons for the rational development of innovative pharmaceutical products”, 16th Israel Materials Engineering Conference (IMEC16). Haifa, Israel 2014. Keynote
  3. “Poly(Vinyl Alcohol)-Based Amphiphilic Nanogels by Non-Covalent Boric Acid Crosslinking”, 34th International Conference of the Polymer Processing Society (PPS-34). Taipei, Taiwan 2018, Keynote
  4. Advanced amphiphilic nanobiomaterials for drug delivery: From design to preclinical evaluation”, 19th International Microscopy Congress (IMC19). Sydney, Australia 2018. Keynote
  5. “Amphiphilic copolymers in advanced drug delivery: From improved mucosal permeability to active targeting”, XVI Latin American Polymer Symposium/XIV Ibero-American Polymers Congress. Mar del Plata, Argentina 2018. Keynote
  6. “Polymeric amphiphiles: Targeting pediatric tumors and beyond”, XIV Congress of the Spanish Society of Pharmaceutics and Pharmaceutical Technology. Santiago de Compostela, Spain 2019. Plenary
  7. 7. “Novel targeted and stimuli-responsive amphiphilic nanobiomaterials”, 13th International Symposium Frontiers in Biomedical Polymers. Puerto de la Cruz, Spain Keynote
  8. “Amphiphilic nanobiomaterials: Is there anything beyond conventional drug encapsulation and release?”, XIII Argentine Polymers Symposium (SAP 2019). Buenos Aires, Argentina 2019. Plenary
  9. “Glycosylated amphiphilic polymeric nanoparticles in active drug targeting”, NanoBio&Med2019, Barcelona, Spain 2019. Keynote
  10. “Nanotechnology strategies to target drugs to the Central Nervous System”, 1st Virtual Annual Meeting of the Argentine Nanomedicine Society (Nanomed-ar 2020). December 2020. Virtual meeting. Plenary
  11. “Actively targeted hybrid TiO2/polymer nanomaterials for sonodynamic therapy of cancer”, 11thInternational Conference of the African Materials Research Society (AMRS2022). Dakar, Senegal 2022. Keynote
  12. “Glucosylated hybrid titanium dioxide/polymer nanomaterials of controlled size for active targeting in the sono-dynamic therapy of cancer”, XXIII Argentine Congress of Physical and Inorganic Chemistry (CAFQUI2023). El Calafate, Argentina 2023. Keynote
  13. “Targeted hybrid titanium dioxide/polymer nanomaterials in the sono-dynamic therapy of cancer”, 12th International Conference for Colloids and Interfaces. Palma de Mallorca, Spain 2023. Keynote
  14. “Sonodynamic therapy of cancer: Challenges and Opportunities”, XII Latin-American Congress of Artificial Organs and Biomaterials (COLAOB 2023), To be held in Mar del Plata, Argentina 2023. Plenary

(B) Invited

  1. “Polymeric nanocarriers in therapeutics: The potential of polymeric micelles in the encapsulation and the stabilization of drugs”. 2nd School of Pharmaceutical Nanotechnology, Bernal, Argentina 2008.
  2. “HIVS/AIDS: Contributions of the Pharmaceutical Sciences to the treatment of the pediatric patient”. III Congreso Colombiano de Biotecnología/II Seminario Internacional de Bionegocios, Bogotá, Colombia 2008.
  3. “In the name of the virus, the Active Pharmaceutical Ingredient and the infected patient: Challenges and potential contributions of Pharmaceutical Technology to the treatment of HIV/AIDS”. BIOOMAT-1st WORKSHOP on BIOMATERIALS, ARTIFICIAL ORGANS AND TISSUE ENGINEERING. Rosario, Argentina 2009.
  4. “The transmutation of the being: From medical devices to novel drug delivery systems”. I Congreso Latinoamericano de Farmacia y Bioquímica Industrial. Buenos Aires, Argentina 2009.
  5. “Infección por el Virus de la Inmunodeficiencia Humana (VIH): Perspectivas para el bordaje multidisciplinario de la farmacoterapia”. NanoMercosur 2009. Buenos Aires, Argentina.
  6. “Small Changes are Big Steps: Making Nanotechnologies Ethically Affordable in Pediatric HIV Pharmacotherapy. First World Conference on Nanomedicine and Drug Delivery”. Kottakam, India 2010.
  7. “Microwave radiation applied to the synthesis of biomaterials”. III Encuentro de Jóvenes Investigadores en Ciencia y Tecnología de Materiales. Concepción del Uruguay, Argentina 2010.
  8. “Nanotecnologías en la optimización de la farmacoterapia del VIH: Estado-del-Arte”. 2nd Latin American School of Nanomedicines. La Plata, Argentina 2010.
  9. “Micelas poliméricas como herramienta nanotecnológica versátil en la optimización de la biodisponibilidad oral de fármacos”. 2nd Latin American School of Nanomedicines. La Plata, Argentina 2010.
  10. “Nuevos-viejos desafíos en el tratamiento de la tuberculosis”. 2nd Latin American School of Nanomedicines. La Plata, Argentina 2010.
  11. “Aplicaciones de biomateriales a la liberación de fármacos en veterinaria”. ETIF 2010 Congress and Exposition”. Buenos Aires, Argentina 2010.
  12. “Embracing the spirit of the “Make medicines children size” campaign in HIV/AIDS: How nanotechnologies can make it”. 1st South American Congress of Biopharmacy and Pharmacokinetics/Panamerican Congress of Pharmacy. Porto Alegre, Brazil 2010.
  13. “The pros and contras of innovation: Issues to take advantage of novel technologies in neglected diseases, the HIV case. First Workshop on Nanomedicine for Infectious Diseases of Poverty: Perspectives and Possibilities”. Magaliesberg, South Africa 2011.
  14. “Copolímeros anfifílicos auto-agregables como inhibidores de transportadores de eflujo en la optimización de la farmacoterapia”. Encuentro Anual de la Sociedad Argentina de Farmacología Experimental. Tucumán, Argentina 2011.
  15. “Liberación controlada de antibióticos en el tratamiento de lesiones de piel”. I Argentine Symposium on Medical Devices and Sterilization. Buenos Aires, Argentina 2011.
  16. “Contributions of nanotechnology to the improvement of Poverty Related Diseases”. XI Meeting on Surfaces and Nanostructured Materials 2011. San Martín, Argentina 2011.
  17. “Nanotechnology-based strategies for drug delivery and targeting in poerty-related and infectious diseases”. Joint Binational Workshop of the University of Buenos Aires and the University of Freiburg. Freiburg in Breisgau, Germany 2012.
  18. “Nano for HIV”. ICPC Nanonet Project. May 2012 (webinar).
  19. “Self-assembling amphiphilic copolymers as inhibitors of ATP-binding cassette pumps”. XXI International Materials Research Congress. Cancun, Mexico 2012.
  20. “Nanotechnology-based strategies for drug delivery and targeting in HIV: Development of an innovative pediatric product of the antiretroviral efavirenz”. II National Nanotechnology Congress. Viña del Mar, Chile 2012.
  21. “Innovación en el desarrollo de productos farmacéuticos en enfermedades desatendidas: El caso VIH”. 3rd Latin American School of Nanomedicines, Potrero de los Funes, Argentina 2012.
  22. “Micelas poliméricas como herramientas para el transporte y el abordaje de la resistencia a fármacos”. 3rd Latin American School of Nanomedicines. Potrero de los Funes, Argentina 2012.
  23. “Nanotechnology-based strategies for enhanced biopharmaceutic performance in the pharmacotherapy of HIV”. International Meeting of Pharmaceutical Sciences-RICIFA 2012. Rosario, Argentina 2012.
  24. “Polymeric micelles for the enhanced biopharmaceutic performance of the antiretroviral efavirenz”. Regional Meeting of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Buenos Aires, Argentina 2012.
  25. “Perspectives in nanomedicine research in Poverty-related diseases”. II Argentine Nanomedicine Symposium. Buenos Aires, Argentina 2013.
  26. “Finding the Balance between Innovation and Bench-to-bedside Translation in HIV Therapy”, CLINAM 7/2014-The European Summit for Clinical Nanomedicine and Targeted Medicine, European Foundation for Clinical Nanomedicine. Basel, Switzerland 2014.
  27. “Polymeric micelles for improving the oral bioavailability of drugs: From self-assembly to bench-to-bedside translation”, 2014 IUPAC World Polymer Congress-MACRO 2014. Chiang Mai, Thailand 2014.
  28. “Pediatric nanomedicine: Minimizing the size to maximize the benefit”, Global Research in Pediatrics (GRiP) Network of Excellence “Meet the expert in pediatric formulation”, July 2014 (webinar).
  29. “Do not forget the forgotten diseases…and patients”, Annual Meeting of the Israeli Chapter of the Controlled Release Society. Ma’alot, Israel 2014.
  30. “Nanomedicine for kids: The size matters”, International Course on Tissue Engineering, Regenerative Medicine, and New Materials for the Design of Drug Delivery Systems in High Socioeconomic Impact Diseases. Bogotá, Colombia 2014.
  31. “Polymeric micelles for oral drug delivery applications”, International Course on Tissue Engineering, Regenerative Medicine, and New Materials for the Design of Drug Delivery Systems in High Socioeconomic Impact Diseases. Bogotá, Colombia 2014.
  32. “Potential of polymeric micelles as drug carriers for non-parenteral routes”, 29th Umbrella Symposium Technion-RWTH Aachen University-Julich Forschungszentrum. Haifa, Israel 2015.
  33. “The pros and the cons of polymeric micelles as delivery platform by minimally-invasive administration routes: Make it the sticky way”, CLINAM 8/2015-The European Summit for Clinical Nanomedicine and Targeted Medicine, European Foundation for Clinical Nanomedicine. Basel, Switzerland 2015.
  34. “Nano-Drug Delivery Platforms for Improved Therapy of HIV: Only a Scientific Challenge?” Sydney Nanomedicine Conference. Sydney, Australia 2015.
  35. “Spray-drying versus electrohydrodynamic atomization for the encapsulation of water-soluble drugs”, XXIV International Materials Research Congress. Cancun, Mexico 2015.
  36. “Potential of non-covalently crosslinked polymeric micelles as more versatile nano-drug delivery systems”, XXIV International Materials Research Congress. Cancun, Mexico 2015.
  37. “Innovation in the development of pharmaceutical products for neglected diseases: Some lesson learned from the HIV case”, First Conference on Clinical Nanomedicine. Caracas, Venezuela 2015 (skype conference).
  38. “Novel self-assembly nanocarriers stabilized with mild chemistries”, 81st Meeting of the Israel Chemical Society. Tel Aviv, Israel 2016.
  39. “Polymeric Micelles as a Nano-Drug Delivery System Model: Can We Find a Balance between Sophistication and Clinical Translation?” The First NIMS (Japan) – Technion (Israel) Workshop on “Innovative Materials and Nanotechnology”. Tsukuba, Japan 2016.
  40. “Paediatric Nanomedicine: Challenges to Close the Adult-child Gap Before it Emerges”, CLINAM 9/2016-The European Summit for Clinical Nanomedicine and Targeted Medicine, European Foundation for Clinical Nanomedicine. Basel, Switzerland 2016.
  41. “Non-covalently crosslinked multimicellar systems for more efficient drug delivery applications”, Asian Polymer Association (APA) International Conference on Advanced Polymers, Biomaterials, Bioengineering & Nano Drug Delivery. Flic-En-Flac, Mauritius 2016.
  42. “Innovative strategies for the synthesis of self-assembly amphiphilic nanobiomaterials with advanced features”, Royal Society of Chemistry Biomaterials Interest Annual Conference 2017. Belfast, UK 2017.
  43. “Novel strategies for the design of organic-inorganic amphihilic nanobiomaterials for improved performance in drug delivery”, 45th Annual Meeting of The Israeli Polymer and Plastic Society (IPPS). Ramat Gan, Israel 2017.
  44. “Polymeric micelles stabilized by drug-compatible chemical pathways”, 8th International Congress BioNanoMed 2017. Krems an der Donau, Austria 2017.
  45. “Advanced self-assembly polymeric nanobiomaterials: From design to engineering”, 9th International Conference on Materials for Advanced Technologies (ICMAT2017). Singapore 2017.
  46. “Polymeric micelles as drug delivery platform: Challenges and opportunities”, Controlled Release Society-CoreNet Networking Symposium. Singapore 2017.
  47. “Novel polymer-ceramic hybrid amphiphilic nanomaterials with superior properties for drug delivery applications”, Biomaterials International 2017. Fukuoka, Japan 2017.
  48. “Sol-gel in biomedical applications: From pure ceramics to polymer-ceramic hybrids”, 8th School for the Synthesis of Materials: Sol-Gel Processes. Buenos Aires, Argentina 2017.
  49. “Pathways for the targeting of nano-drug delivery systems in pediatric disease”, 2nd International Conference on Biomedical Applications of Nanomaterials (ICOBAN2018). Hong Kong, China 2018.
  50. “Carbohydrate pathways to target sugar-avid pediatric tumors with nanomedicines”, 18th Israel Materials Engineering Conference (IMEC18). Dead Sea, Israel 2018.
  51. “Amphiphilic polymeric nanocarriers for mucosal drug delivery”, Annual Meeting of the European Network of Bioadhesive Expertise. Barcelona, Spain 2018.
  52. “Amphiphilic Nanobiomaterials for Advanced Drug Delivery”, 2018 European Materials Research Society Spring Meeting and Exhibit. Strasbourg, France 2018.
  53. “Amphiphilic nanobiomaterials in drug delivery: From design to application”, Advanced Materials for the 21st Century, KAIST – Technion – GTIIT Workshop, Haifa, Israel 2018.
  54. “Amphiphilic polymeric nanocarriers to overcome biological barriers”, XXVII International Materials Research Congress. Cancun, Mexico 2018.
  55. “Glycosylated self-assembled nanocarriers for active drug targeting of pediatric patient-derived tumors”, XI Meeting of the Israeli Chapter of the Controlled Release Society. Ma’alot, Israel 2018.
  56. “Amphiphilic polymeric nanoparticles to cross biological barriers in drug delivery”, 33° Latin-American Congress of Chemistry (33-CLAQ). Havana, Cuba 2018.
  57. “Capitalizing on the metabolism of glucose to target tyrosine kinase inhibitor nanomedicines to pediatric patient-derived sarcomas”, International Meeting on Pediatric Sarcomas and Rare Tumors. Haifa, Israel 2019.
  58. “Sono-responsive hybrid titanium oxide/polymer nanomaterials”, 10th International Conference on Materials for Advanced Technologies (ICMAT2019). Singapore 2019.
  59. “Drug delivery fundamentals and applications in tissue engineering”, Summer School on Biomaterials and Regenerative Medicine, Mongolian University of Science and Technology, Ulan Bator, Mongolia 2019.
  60. “Novel hybrid amphiphilic nanoparticles for sonodynamic therapy”, 8thAsian Conference on Colloid and Interface Science(ACCIS 2019). Kathmandu, Nepal 2019.
  61. “The potential of amphiphilic nanobiomaterials in drug delivery and targeting”, 10thInternational Conference of the African Materials Research Society (AMRS2019). Arusha, Tanzania 2019.
  62. “Microtechnologies and nanotechnologies applied to improve the treatment of disease”, Israel Innovation Workshop at the Technion for Chinese Business Executives. Haifa, Israel 2020.
  63. “The quest for nanotechnology platforms to target the central nervous system”, CLINAM 12/2020-The European Summit for Clinical Nanomedicine and Targeted Medicine, European Foundation for Clinical Nanomedicine. Basel, Switzerland 2020. Virtual meeting
  64. “Strategies for drug targeting to the Central Nervous System”. International Meeting of Pharmaceutical Sciences-RICIFA 2020-2021 Virtual Conference Series. Virtual meeting.
  65. “Surface-modified polymeric nanoparticles to target the brain”, Biomaterials International 2021. Taiwan 2021. Virtual meeting.
  66. “Polymeric nanoparticles surface-modified with peptides to target the Central Nervous System”, 2021 International Conferenceon Electronic Materials and the XIX Brazil MRS Meeting. Brazil 2021. Virtual meeting.
  67. “New insights to target nano-drug delivery systems to the central nervous system”, 12th Meeting of the Israeli Chapter of the Controlled Release Society. Ma’alot, Israel 2021.
  68. “Hybrid ceramic/polymer nanomaterials for sono-dynamic therapy of cancer: Is it all about sono-responsiveness?”, 4th Virtual European Polymer Conference. 2023. Virtual meeting.
  69. “Novel hybrid nanomaterials for sonodynamic therapy of solid tumors”, Biomaterials International 2023. Sapporo, Japan 2023.
  70. “Hybrid TiO2-based nanomaterials for sono-dynamic therapy of cancer”, 13th Meeting of the Israeli Chapter of the Controlled Release Society. Galilion Hotel, Israel 2023.
  71. “Self-assembled polymeric nanocarriers in drug delivery and targeting”, Biomaterials International 2024. To be held in Bangkok, Thailand in June-July 2024.
  72. “TBD”, 12thInternational Conference of the African Materials Research Society (AMRS2024). To be held in Kigali, Rwanda in December 2024.
  73. “TBD”, 11th International Conference on Advanced Materials & Nanotechnology (AMN11). To be held in Christchurch, New Zealand in February 2025.