ד"ר יהושע מ. גרולמן

2020, Postdoctoral Fellowship, Harvard University
2016, Ph.D., Materials Science and Engineering, University of Illinois at Urbana-Champaign
2011, B.S., Biochemistry, University of Massachusetts  at Amherst

Nuutila K, Grolman J, Yang L, Broomhead M, Lipsitz S, Onderdonk A, Mooney D, Eriksson E. “Immediate Treatment of Burn Wounds with High Concentrations of Topical Antibiotics in an Alginate Hydrogel Using a Platform Wound Device.” Adv Wound Care, 2020.

Grolman, J.M.; Weinnand, P.; Mooney, D.J. “Extracellular matrix plasticity as a driver of cell spreading” PNAS, 2020.

Grolman, J.M.; Mansher S.; Mooney, D.J.; Eriksson, E.; Nuutila, K. “Antibiotic-containing agarose hydrogel for wound and burn care,” Burn Care and Research, 2019.

Winterberg, S.; Shachar, C.; Lunshof, J.; Grolman, J.M. “Technology Fact Sheet: Genome Editing.” Belfer Center for Science and International Affairs. 2019.

van der Valk, D.C.*; van der Ven, C.F.T.*; Blaser, M.C.*; Grolman, J.M.; Wu, P.J.; Fenton, O.S.; Lee, L.H.; Tibbitt, M.W.; Andresen, J.L.; Wen, J.R.; Ha, A.H.; Buffolo, F.; van Mil, A.; Bouten, C.V.C.; Body, S.C.; Mooney, D.J.; Sluijter, J.P.G.; Aikawa, M.; Hjortnaes, J.; Langer, R.; Aikawa, E. “Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics,” Nanomaterials, 2018, 8, 296-317.

Montoto, E.; Gavvalapalli, N.; Hui, J.; Burgess, M.; Sekerak, N.; Hernandez-Burgos, K.; Wei, T.-S.; Kneer, M.; Grolman, J.; Cheng, K.; Lewis, J.; Moore, J.; Rodriguez-Lopez, J. “Redox Active Colloids as Discrete Energy Storage Carriers,” J. Am. Chem. Soc. 2016, 138, 13230–13237.

Grolman, J.M.; Zhang, D.; Smith, A.M.; Moore, J.S.; Kilian, K.A. “Rapid 3D Extrusion of Synthetic Tumor Microenvironments, Adv.Mater., 2015, 27, 5512-5517 (selected front cover art).

Grolman, J.M. “Methods of Extruding Multilayer Fibers,” Patent Application WO2016172707A1.

Grolman, J.M.; Inci, B.; Moore, J.S. “pH-Dependent Switchable Permeability from Core-Shell Microcapsules,” ACS Macro. Lett., 2015, 4, 441-445.

Mammalian cell morphology is a key determinant of function, igniting significant interest in understanding how cell phenotype is regulated by microenvironmental cues. These cues include cell-cell interactions, soluble signaling molecules, and adhesion to the extracellular matrix (ECM) via transmembrane receptors; the physical properties of the ECM, particularly its stiffness and rate of stress relaxation are known to regulate the ability of a variety of cell types to spread and differentiate in 2D and 3D culture. However, many of these properties are interconnected and developing material systems to isolate individual properties becomes an important tool; a tool that allows for the investigation of the changes ECM materials undergo to better understanding disease states and the therapeutic opportunities. My laboratory will tackle these issues by synthesizing novel polymeric architectures to study prenatal membrane rupture, keratinocyte stem cell differentiation and callus formation, the timescales of immune cell mechanotransduction, and developing new tools to measure in situ mechanical forces in viscoelastic materials. My training in materials science has me uniquely positioned to not only synthesize new tools and methods to study ECM interactions, but in adapting our findings and working with interdisciplinary teams to apply them for therapeutic and commercial benefit.

Freedom from Cancer Startup Challenge Winner                                                                                                      2018
UMass Boston Guest Lecturer in Biology                                                                                                                     2017
NSF National Innovation CORPS Fellowship: Team Leader                                                                                   2016
COZAD New Venture Competition Winner                                                                                                                 2016
Fifty for The Future                                                                                                                                                           2016
Illinois Innovation Prize Finalist                                                                                                                                    2016
CASSS Travel Award                                                                                                                                                          2015
Illinois Conference Travel Award                                                                                                                                    2015
Intel-Racheff Award Finalist                                                                                                                                 2015, 2016
NSF IGERT Graduate Research Fellowship                                                                                                        2011-2013
NSF EAPSI Fellowship Awardee                                                                                                                                       2013
Commonwealth College Honors College Scholar and Research Fellow                                                         2007-2011
Junior Fellow in the Life Sciences at UMass Amherst                                                                                                  2010
UMass Writing Program Outstanding Essay Award                                                                                                     2007