Ms. Dareen Sader - M.Sc. candidate
02/06/2024
אודיטוריום ע"ש דויד וואנג, בניין מידן, קומה 3
14:30
With its rapid development in the past decades, gene therapy has shown great therapeutic potential for diverse life-threatening diseases. One of the mechanisms that have been adopted as a functional genomic tool is RNA interference, a naturally occurring regulatory mechanism in which small interfering RNA (siRNA) molecules are responsible for sequence-specific suppression of gene expression. The integration of RNA interference with nanotechnology can help not only overcome the challenges associated with siRNA but also convert some of them into advantages. In this framework, we focus on the exploration of polyelectrolyte complex nanoparticles as delivery systems for siRNA, thus enhancing the targeting ability and eventually enabling the down-regulation of specific genes and decreasing the expression of the proteins encoded by them.