Prof. Witold Łojkowski
22/02/2026
אודיטוריום ע"ש דויד וואנג, בניין מידן, קומה 3
13:30
The treatment of challenging bone defects caused by trauma, tumour resection, or joint replacement remains a major clinical problem. This work focuses on the synthesis and application of nanostructured hydroxyapatite with precisely controlled particle sizes in the range of 10–42 nm as well as implants coated with these particles, and their application in bone regeneration in veterinary medicine.
Microwave Hydrothermal Synthesis (MHS) reactors were used to produce biomimetic hydroxyapatite (GoHAP). Sono-Nano-Coating (SNC) technology was applied to modify implant surfaces (#D scaffolds, membranes) with GoHAP layers, and biodegradable GoMEMBRANE memebranes were developed for guided bone regeneration. Biocompatibility of GoHAP and GoMEMBRANE was evaluated in accordance with ISO 10993. Both materials are manufactured in compliance with ISO 13485 requirements for medical devices.
Six distinct GoHAP nanoparticle size fractions were obtained. The smallest particles exhibit a crystal structure closely resembling cortical bone, as confirmed by X-ray diffraction analysis. Increased calcium ion release was observed for smaller nanoparticles, indicating a potential for accelerated bone regeneration. The effectiveness of GoHAP as a bone graft material was demonstrated in veterinary trials, while GoMEMBRANE was successfully applied in splint bone reconstruction in horses. Both materials are ready for clinical evaluation.
Further studies investigated hierarchical nanocomposite coatings composed of nanoparticles with different sizes and compositions, including GoHAP combined with nanoZnO and nanoAg. The potential for functionalisation with antibiotics or growth factors was also examined. In vitro, in vivo, and in ovo studies were performed. The work concludes with a brief overview of the research pathway leading to these results, presented as a case study in materials research.