Composite Gelatin-Alginate Hydrogels as Bioadhesive Materials and Scaffolds for Tissue Regeneration – לזכרו של פרופסור ארנון זיגמן ז"ל

אודיטוריום ע"ש דיוויד וואנג, קומה 3, בנין דליה מידן
Prof. Meital Zilberman

סמינר לזכור של פרופסור ארנון זיגמן, שנפטר בשנה שעברה

Prof. Meital Zilberman
Dept. of Biomedical Engineering, Faculty of Engineering, Tel-Aviv University
Tel-Aviv 69978, ISRAEL

Novel hydrogels based on the natural polymers gelatin and alginate were recently developed and studied by us for bioadhesive and tissue engineering applications. The combination of these materials resulted in high strength, high biocompatibility and additional desired properties that can be tailored for specific for specific biomedical applications. Unique bioadhesives were achieved when loaded the basic formulations with functional additives, such as hemostatic agents, drug molecules and bioactive ceramics. Addition of the hemostatic agent kaolin improved the adhesion, sealing ability and overall function in a hemorrhagic environment. Delivering an antibiotic drug locally using our bioadhesive decreased the risk of infections and increased the therapeutic effect of the bioadhesive. These multifunctional hydrogel systems will be described in terms of formulation-structure-property effects as well as in-vivo results. They actually behave as composite bioadhesives and scaffolds for tissue engineering, and thus present a new concept of biomaterials. The understanding of the relationships between formulation parameters, structure and the resulting relevant in-vitro properties and in-vivo functioning, are of great scientific and medical relevance. They are expected to provide new solutions to basic needs in various medical fields.

ESEM micrographs
ESEM micrographs showing the structure of the composite bioadhesives loaded with: (a) The hemostatic agent kaolin, (b) the analgesic drug bupivacaine, (c) hydroxyapatite.