Polymeric micelle-like nanocarriers based on the conjugation of amphiphilic diblocks to the surface of a multifunctional anchor

David Wang Auditorium, 3rd floor Dalia Maydan Bldg
Doaa Abu Saleh. M.Sc. candidate

Doaa Abu Saleh. M.Sc. candidate Department of Materials Science and Engineering, Technion – Israel Institute of Technology, Haifa, Israel

Polymers play a major role in pharmaceutical and drug delivery by providing flexible platforms for controlled release and targeting. The poor aqueous solubility and the physicochemical stability of many drugs is one of the most challenging issues in pharmaceutical development. Polymeric micelles (PMs) represent a nanotechnology platform largely used to solubilize and stabilize drugs and increase their oral bioavailability. They are the result of the self-assembly of amphipathic copolymer chains in water above the critical micellar concentration (CMC) and display two domains, a hydrophobic core and a hydrophilic corona. The hydrophobic core fits the encapsulation poorly water-soluble molecules, and the corona that is in direct contact with the medium, stabilizes the aggregate and tunes the release of the cargo. However, a main challenge is preventing the disassembly of PMs under dilution in the body fluids, which leads to uncontrolled release of the encapsulated cargo. This project investigated a new amphiphile architecture, namely core-anchored PMs, to improve the physical stability and performance of these nanocarriers. In this framework, cyclodextrins and carboxylated nanodiamonds (cNDs) were used as molecular anchor for the conjugation of amphipathic oligomeric chains made of hydrophobic poly(epsilon-caprolactone) and poly(ethylene glycol) monomethyl ether (mPEG) as hydrophilic corona. Results support the feasibility of this strategy for the development of more robust nanotechnology platforms for drug delivery

Supervisor: Prof. Alejandro Sosnik