Engineering Bioactive Functional Polymers and Delivery Systems for Long-Term Therapies

David Wang Auditorium, 3rd floor Dalia Maydan Bldg.
Dr. Shady Farah

Dr. Shady Farah, Invited Speaker

Department of Chemical Engineering and David H Koch Institute, Massachusetts Institute of Technology (MIT)

500 Main Street, Cambridge, MA 02139, USA.

The talk will be divided into two parts representing selected PhD and current postdoctoral studies.

The first will briefly discuss engineering functionalized polymers, synthesis and manipulations for acquiring different physical, mechanical and functional properties for addressing different needs. Also, it will cover engineering multi-layer polymer-based delivery systems and crystalline coatings for tiny medical devices.

The second part will discuss the rational design and engineering of long-term releasing compact crystals and modified polymers for localized suppression of foreign body response (FBR) for medical devices including polysaccharide-encapsulated beta-cells for the treatment of type 1 diabetes.

Implantable medical devices have revolutionized modern medicine and treatment approaches; however, their benefits and long-term use are undermined by immune-mediated FBR and implant failure. As such, there is a critical need not only for targeted, localized delivery, but also for extended long-term release systems that overcome this key challenge beyond the shorter timeframes allowed by current technologies.

Polysaccharide modification chemistry and structure-activity relationships will be discussed. The long-term releasing compact crystals will be presented using localized fibrosis prevention as a model. Lastly, tentative future projects for advanced polymers and materials will be presented.