Research Interests and Methods

RESEARCH INTERESTS AND METHODS

Research interestMethods usedMain characterization tools
Self-assembly, crystallization phenomena and production of pure drug nanoparticlesNanoprecipitation,
Nano spray-drying
NMR, FTIR, DLS, NanoSight,
X-Rays, DSC, advanced microscopies
Synthesis and characterization of polymeric biomaterialsMicrowave-radiation, thermal methodsNMR, FTIR, elemental analysis,
GPC, DSC, TGA
New polymeric microcarriers and nanocarriers (mucoadhesive and self-assembly systems)Nano spray-drying, nanoprecipitation, ionotropic gelation, microencapsulation DLS, NanoSight, advanced microscopies
Drug encapsulation, delivery and targetingVarious DLS, NanoSight,
HPLC, UV
In vitro and ex vivo studiesCell culture and mammal tissues (e.g., bovine intestine)DLS, NanoSight,
HPLC, fluorescence, flow cytometry
Preclinical studiesPharmacokinetics, targetingSmall animals/In collaboration
Clinical studiesAdult healthy volunteersIn collaboration

 

RELEVANT EXAMPLES OF OUR RESEARCH

NON-COVALENTLY CROSSLINKED AMPHIPHILIC NANOPARTICLES FOR DRUG DELIVERY

Read about this research

https://www.sciencedirect.com/science/article/pii/S073497501500004X?via%3Dihub

https://www.futuremedicine.com/doi/10.2217/nnm.15.191

http://pubs.rsc.org/en/content/articlehtml/2017/bm/c7bm00675f

http://pubs.rsc.org/en/content/articlehtml/2017/bm/c6bm00667a

http://www.mdpi.com/2073-4360/10/5/478

 

GLUCOSYLATED POLYMERIC MICELLES THAT TARGET PATIENT-DERIVED PEDIATRIC TUMORS

Read about this research

https://www.sciencedirect.com/science/article/pii/S2352940717304766

https://www.sciencedirect.com/science/article/pii/S0168365918301111?via%3Dihub

 

POLYMER-CERAMIC AMPHIPHILIC NANOPARTICLE-IN-NANOPARTICLE DELIVERY SYSTEMS

Read about this research

https://pubs.acs.org/doi/abs/10.1021/acs.chemmater.6b04922?mi=aayia761&af=R&AllField=nano&target=default&targetTab=std

 

NANOPARTICLE-IN-MICROPARTICLE DELIVERY SYSTEMS

Read about this research

https://www.sciencedirect.com/science/article/pii/S1742706118302484


Funding

Marie_Curie_sponsor           European_Commission_sponsor   Technion_sponsor

Volkswagen_stiftung_sponsor

Phyllis and Joseph Gurwin Fund for Scientific Advancement

Israeli-Science-Foundation   teva nne

euronanemed2               משרד הבריאות

 

NEVET Nanotechnology Grant

 

Uzi and Michal Halevy Fund

Technion Australia


 

PRESENTATIONS AVAILABLE IN THE WEB

“Polymeric micelles for oral drug delivery” (in Spanish)

Institution: Faculty of Pharmacy and Biochemistry, University of Buenos Aires

Link: https://docs.google.com/file/d/0ByjUS8JXCeQ8R2ZpOXRJVlhLcnM/preview


“Nanomedicines for children: Minimising the size to maximise the benefit” (in English)

Institution: “Meet the Expert in Paediatric Formulations”-Global Research in Pediatrics (GRiP) Network of Excellence

Link: http://www.grip-network.org/index.php/en/news/item/48


“Polymeric micelles for oral drug delivery” (in Spanish)

Event: International Course on Tissue Engineering, Regenerative Medicine and New Materials for the Design of Drug Delivery Systems in High Socioeconomic Impact Diseases, Bogota, Colombia

Link: https://www.youtube.com/watch?v=nRXGGybK2aA


“Pediatric nanomedicine: The size matters…” (in Spanish)

Event: International Course on Tissue Engineering, Regenerative Medicine and New Materials for the Design of Drug Delivery Systems in High Socioeconomic Impact Diseases, Bogota, Colombia

Link: https://www.youtube.com/watch?v=2ae5qFQxX28


Finding the Balance between Innovation and Bench-to-bedside Translation in HIV Therapy” (in English)

Event: 7th CLINAM 2014, Basel, Switzerland

Link: https://www.youtube.com/watch?v=c0-SaQwjl20


 

Links to professional and general media