Nanoelectrochemistry at the Single Entity Level

seminars
01.01.2017
14:30
אודיטוריום ע"ש דיוויד וואנג, קומה 3, בנין דליה מידן
Dr. Lior Sepunaru

Dr. Lior Sepunaru
Department of Chemistry, Physical and Theoretical Chemistry Laboratory, Oxford University, Oxford OX1 3QZ, United Kingdom

During the past few years, the field of electrochemistry has revolutionized with the development of new techniques that enable simple, accurate and rapid measurements aiming to investigate reactions at the nanoscale.1 During this talk, I will overview some of the cutting edge scientific findings related to in situ single nanoparticle detection and quantification via nanoelectrochemistry.2–4 After that, we will move towards biological molecules. I will demonstrate that single virus and bacteria can be ‘tagged’ with silver nanoparticles and thus transformed into an electroactive species.5,6 Consequently, real time rapid detection of biomolecules at the single entity level is realized. Furthermore, if the biomolecule contains catalytic sites, the activity may be observed without labelling as will be shown for the case of single red blood cell detection.7,8 Last, I will share some future ideas related to this topic together with potential applications to both fundamental science and bioelectronic devices.

References:
1. M. Heyrovsky and J. Jirkovsky, Langmuir, 1995, 11, 4288–4292.
2. Y.-G. Zhou, N. V. Rees and R. G. Compton, Angew. Chem. Int. Ed., 2011, 50, 4219–4221.
3. X. Xiao and A. J. Bard, J. Am. Chem. Soc., 2007, 129, 9610–9612.
4. W. Cheng and R. G. Compton, TrAC Trends Anal. Chem., 2014, 58, 79–89.
5. L. Sepunaru, K. Tschulik, C. Batchelor-McAuley, R. Gavish and R. G. Compton, Biomater Sci, 2015, 3, 816–820.
6. L. Sepunaru, B. J. Plowman, S. V. Sokolov, N. P. Young and R. G. Compton, Chem Sci, 2016, 7, 3892–3899.
7. L. Sepunaru, S. V. Sokolov, J. Holter, N. P. Young and R. G. Compton, Angew. Chem., 2016, 128, 9920–9923.
8. J. J. Gooding, Angew. Chem. Int. Ed., 2016, 55, 12956–12958. (* highlight to ref. 7)